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February 18, 2021 6 min read

Choosing a HealthyBrain B-Complex multivitamin formula

One of the most common questions we are asked is, "So how do I know which HealthyBrain vitamin product to choose?"

Excellent question!  We’d love to give you a quick answer, but the fact is, it depends.  Each person has several important health factors that can influence whether or not they could likely benefit from a customized vitamin repletion plan, including specific ingredients and doses.  No two people will have exactly the same needs and therefore the best way to determine this would be to look at laboratory data and genetic data, like MTHFR, and take into account certain known risk factors which affect intake, demand, absorption, metabolism and/or excretion of certain nutrients.  These can be things like particular medications, diet, alcohol use, smoking, and certain health conditions.  Having all this information would be the most accurate way to assess your repletion need.  As a vitamin company, we cannot order and interpret your baseline labs for you (bummer!), but we can at least get you started on a way to screen for some common health issues that can provide an initial estimate of whether you are more likely to be at an overall lower or higher risk for having common states of B vitamin deficiencies or insufficiencies.  It doesn’t take the place of a complete assessment, but it’s at least a good evidence-based, risk-factor-based assessment.  So basically, it’s a good place to start

We’ve tried to take some of the guesswork out by creating the handy little checklist you can find below.  It is important to note that the checklist is not meant to replace standard assessment and treatment services by a medical provider, nor does it constitute medical advice. 

HealthyBrain (HB) B-Complex multivitamin formulas comparison:

No matter which one you choose, both HealthyBrain Immune Boost and HealthyBrain Immune + Mood Boost formulas provide:

  •      √ Balanced B vitamin and mineral-based supports in one capsule including 7 B vitamins + three additional ingredients (N-acetylcysteine, Zinc, Selenium) whose potential…
    •               √ Immune support
    •               √ Antioxidant support
    •               √ Anti-inflammatory support

…effects are currently being studied in several different international Covid-19 supplement-based research studies. [1, 15, 16, 17, 18, 20, 21]

Okay, awesome!  So now that we know what’s similar, let’s look at what’s different:

HealthyBrain Immune Boost

HealthyBrain Immune + Mood Boost

   No MTHFR C677T or A1298C mutations

   1 or 2 MTHFR C677T or A1298C mutations

   Homocysteine (HCY) at an ideal brain health range (5-7 umol/L) or mildly elevated (7-10 umol/L)

   Homocysteine (HCY) at a moderately elevated (10-14 umol/L) or greater threshold range (>=14 umol/L) linked to doubling of dementia risk [b*][3, 19]

   Not taking any medications that can reduce folate (B9) levels

   Taking medications that can reduce folate (B9) levels like Depakote, Lamictal, Tegretol, Metformin, Methotrexate[e*], birth control [7], etc. (for a more complete list, check out our Vitamin B9 blogpost)

   Not taking any medications for heartburn, ulcers, and acid reflux (GERD) that can reduce folate (B9) and (B12) levels.

   Taking medications for heartburn, ulcers, and acid reflux (GERD) that can reduce folate (B9) and (B12) levels.

   No use of alcohol to occasional use of alcohol defined as 0 to < daily use

   Moderate to heavy use of alcohol defined as 1 drink of alcohol/day for women and 2 drinks of alcohol/day for men [6,11, 14]


   Smoking or vaping [12, 13, 14]

   No more than occasional mild problems with focus and concentration

   Moderate to severe problems with focus and concentration [d*]

   No problems with memory

   Mild-to-Moderate memory concerns [c*]

   Absent to occasional mild anxiety and/or mood symptoms

   Past and/or present (current) episodes of anxiety and/or depression and/or mood symptoms [d*][8,9]


Hopefully now you have some idea which HealthyBrain B-Complex multivitamin formula might be a “good fit” for you, at least based on this brief health risk factor screening.  This is a good place to start since having more of the health risk factors listed in the HealthyBrain Immune + Mood Boost column could also increase the potential for having more baseline B vitamin deficiencies in both number and/or severity.  That said, this health screening only looks at risk factors and not actual laboratory or MTHFR results.  For best results, HealthyBrain recommends you consult with your medical provider and ask for lab work to check for potential vitamin deficiencies, homocysteine level, and MTHFR polymorphisms.  Follow-up lab draws can also help to assess for any changes in your vitamin and homocysteine levels over time and assist with fine-tuning vitamin doses.  (Please see our “Important Screening Labs” blog post for more information). 


Remember: A HealthyBrain has “balanced Bs!”



a* – This HB product informational table is not meant to replace standard assessment and treatment services by a medical provider, nor does it constitute medical advice.  While MTHFR mutations and/or B-vitamin deficiencies/insufficiencies are common in the general population, not everyone needs vitamin repletion support.  Vitamin supplement products have great cost-effective health value for vitamin users to the extent that they are replenishing/repleting specific areas of vitamin deficiency/insufficiency.  For best results, HealthyBrain recommends consultation and lab screening with a medical provider before starting any HB B-Complex product since these vitamins were specifically formulated to help replete and balance common MTHFR-related and B-deficiency/insufficiency states.  MTHFR + related lab evaluations can help each vitamin user to establish the need for HB vitamin repletion, assess repletion outcomes, and fine-tune vitamin dosing over time.

b* – Multiple studies now report that dementia risk increases in relation to progressive increasing homocysteine (HCY) levels starting at a moderately elevated level of 10.8 umol/L. [3, 19]  Dementia risk doubles at HCY levels equal to or greater than 14-15 umol/L [3, 19] and increases in a graded fashion thereafter associated with further HCY increases.  Neurotoxic findings/outcomes linked to excessive HCY levels have included: neuronal cell death, increased rate of brain atrophy (shrinkage), neurofibrillary tangles, beta-amyloid plaques, weakened blood-brain barrier (bbb), and Alzheimer’s disease. [10]

c* – Memory concerns generally warrant a medical assessment.  Sudden changes in memory may warrant an emergency medical assessment.

d* – Published studies indicate that several l-methylfolate (5-MTHF) and B-complex products have been able to provide treatment support (mostly adjunctive) in relation to depression, anxiety, and inattentive symptoms.  We believe that our HB products may be able to yield at least comparable benefits, although it is important to note that these products have not yet been formally tests in clinical outcome studies.  Also, notwithstanding potential benefits B-vitamin products are typically not expected to serve as a stand-alone intervention or replacement for psychiatric interventions such as therapy and/or medication treatment, but rather as an adjuvant (“booster”) treatment support. [1;5]

e* – Methotrexate is a medication used to treat rheumatoid arthritis (RA), psoriasis, and cancer.  It is known to reduce the amount of folic acid in the body.  If you take methotrexate for cancer, please do not start a HB without consulting first with your medical provider.



  1. 1. De Flora, S., Balansk, R., La Maestra, S., Rationale for the use of N-acetylcysteine in both prevention and adjuvant therapy of Covid-19. Federal of American Societies for Experimental Biology (2020); 34(10):13185-13193.
  2. 2. Mech, A.W. and Farrah, A. Correlation of clinical response with homocysteine reduction during therapy in reduced B vitamins in patients with MDD who are positive for the a1298c or c677t MTHFR polymorphism.  Journal of Clinical Psychiatry (2016); 77(5):668-671.
  3. 3. Seshadri, S., Beiser A., Selhub, J., et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. New England Journal of Medicine (2002); 346:476-483.
  4. 4. Van Gelder, M.M.H.J., van Rooij, I.A.L.M., Miller, R.K., et al. Teratogenic mechanisms of medical drugs (2010); 16(4):378-394.
  5. 5. Dartois, L.L., Stutzman, D.L., Morrow, M. L-methylfolate augmentation to antidepressants for adolescents with treatment-resistant depression: A case series.  Journal of Child and Adolescent Psychiatry (2019); 29(5):386-391.
  6. 6. Centers for Disease Control and Prevent. (2019, December 30).  Facts about Moderate Drinking.
  7. 7. Shere, M., Bapat, P., Nickel, C., et al. Association between use of oral contraceptives and folate status: A systematic review and meta-analysis.  Journal of Obstetrics and Gynaecology Canada (2015); 37(5):438-438.
  8. 8. Fava, M. and Mischoulon, D. Folate in Depression: Efficacy, Safety, Differences in Formulations, and Clinical Issues. Journal of Clinical Psychiatry (2009) 70(suppl 5):12-17
  9. 9. Young, L.M., Pipingas, A., White, D.J., et al. A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress:  Effects on Healthy and ‘At-Risk’ Individuals.  Nutrients (2019); 11, 2232:1-19.
  10. 10. Mitchell, E., Conus, N., Kaput, J. B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder, and cognitive decline. Neuroscience and Biobehavioral Reviews (2014); 47:307-320.
  11. 11. Khan, K.M., Jialal, I., Folic Acid Deficiency [Updated 2020 Jun 30]. In: StatPearls [Internet}. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from:
  12. 12. Rabjohn, P. The role and postulated biochemical mechanism of l-methylfolate augmentation in major depression: A case report. Psychiatric Annals (2014); 44(4):197-204.
  13. 13. Croff, J.M., Chiaf, A.L., Hartwell, M.L, et al. Electronic Nicotine Delivery Systems and Serum Folate: A Case Study. Tobacco Use Insights (2109); 12:1-4.
  14. 14. Okumura, K. and Tsukamoto, H. Folate in smokers. Cinica Chimica Acta (2011); 412:521-526.
  15. 15. Laforge, M., Elbim, C., Frère, C. et al. Tissue damage from neutrophil-induced oxidative stress in Covid-19. Nature Reviews Immunology (2020); 20:515-516.
  16. 16. Poe, F.L. and Corn, J. N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2.  Medical Hypotheses (2020); 143;1-4.
  17. 17. Sahebnasagh, A., Saghafi, F., Avan, R. et al. The prophylaxis and treatment of potential supplements for COVID-19. European Journal of Pharmacology (2020); 887:1-10.
  18. 18. Zhongcheng, S., Puyo, C. N-Acetylcysteine to combat Covid-19: An evidence review. Therapeutics and Clinical Risk Management (2020); 16:1047-1055.
  19. 19. Whalley, L.J., Duthie, S.J., Collins, A.R. et al. Homocysteine, antioxidant micronutrients and late onset dementia. European Journal of Nutrition (2014); 58:277-285.
  20. 20. Soto, M.E., Guarner-Lans, V., Soria-Castro, E., et al. Is antioxidant therapy a useful complementary measure for Covid-19 treatment?  An algorithm for its application.  Medicine (2020); 56:1-29.
  21. 21. The Centre for Evidence-Based Medicine. (2020, April 14). N-acetylcysteine: A rapid review of the evidence for effectiveness in treating COVID-19. Available from:



Curt Sturos, MD and Melanie Kabot-Sturos, PMHNP-BC, cofounders of HealthyBrain.  December 4, 2020.