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Clinician-derived B-complex formula including premium grade doses of l-methylfolate (B9) methylcobalamin (B12), riboflavin (B2), Pyroxidal-5-Phosphate (B6), non-flushing Niacinamide (B3), B1, B2, B5, Zinc, and Selenium.
Science-backed health benefits include:
✅ Increased glutathione support. Multi-nutrient regimen helps to maintain healthy glutathione levels in two different ways: B6,B9,B12 provide essential micronutrients needed for glutathione (GSH) production while B2 supports glutathione recycling.
✅ A fortified 30 mg B2 dose provides additional nutrient support for mitochondrial, energy, and ATP metabolism.
✅ Neurotransmitter synthesis support. B1,B2,B3,B5,B6,B9, and B12 vitamins support the natural production of dopamine, serotonin, norepinephrine, and acetylcholine inside neurons. Increased neurotransmitter production is believed to be one of the main mechanisms by which targeted B vitamin replenishment can result in improvements in mental health symptoms.
✅ B2,B6,B9, and B12 are also essential for the normal metabolic clearance of an amino acid called homocysteine, which is harmful when elevated. By supporting homocysteine metabolism, B vitamins also reduce the risk for neurotoxic homocysteine accumulations (ex: levels >10) that have been linked to increased psychiatric symptoms, dementia, and cognitive decline. Elevated homocysteine levels are also associated with erectile dysfunction, blood vessel injury, and increased frequency of blood clots. Common risk factors for elevated homocysteine levels include MTHFR mutations, lower B vitamin levels, COVID-19, long-COVID, excessive alcohol consumption, smoking, and unhealthy nutrition.
✅ Contains L-methyl folate instead of synthetic folic acid. L-methyl folate is a bioactive form of folate that offers multiple advantages over synthetic folate (also known as folic acid) due to not requiring additional chemical modifications through several extra metabolic steps before it can be used by most cells in the body, including brain cells. This is particularly beneficial in people at increased risk for impaired folate metabolism, which includes people with multiple B vitamin insufficiencies, people taking seizure meds, and people with MTHFR mutations. People with MTHFR mutations usually have impaired folate metabolism in addition to a reduced ability to naturally produce L-methyl folate. According to study data, about 50% of the general population, up to 90% of people presenting to psychiatry specialty clinics, and up to 90-93% of people presenting to dementia clinics are likely to have MTHFR mutations. L-methyl folate also has been shown to have greater mental health benefits for improving mental health symptoms such as depression compared to folic acid. In addition, L-methyl folate is also the only form of B9 that can pass through the blood brain barrier, while folic acid can competitively block L-methyl folate from passing through the blood brain barrier. In short, from a mental health support perspective, L-methyl folate has several advantages over synthetic folic acid.
✅ Contains zinc and selenium, insufficiencies of which have been associated with depression, inattentive symptom, and worse Covid-19 outcomes.